Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → 1,5-Dihydro-3-methoxy-2,4-benzodioxepin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | 1,2-Benzenedimethanol | HCID 69153 | — |
| 반응물 | 3-(1-propenyl)-1,5-dihydro-3H-2,4-benzodioxepine | HCID 53720123 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 1,5-Dihydro-3-methoxy-2,4-benzodioxepin | HCID 3795208 | 89% |
반응 단계
A method for synthesizing 3-(1-propenyl)-1,5-dihydro-3H-2,4-benzodioxepine is illustrated in Scheme 3. 1,2-Benzenedimethanol (500 mg, 3.62 mmol) and p-toluenesulfonic acid (172 mg, 0.9 mmol) were dissolved in 2 mL of dry DME and triethylortoformate (0.396 mL, 3.62 mmol) was added. The solution was stirred at rt. and under argon for 1 h. Ether (20 mL) was added and the organic layer washed with a saturated solution of NaHCO3 and water, then dried (Na2SO4). The solvent was evaporated giving crude 3-methoxy-1,5-dihydro-3H-2,4 benzodioxepine as a colorless oil (526 mg, 89%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713287B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-6acbabc4189d4bf5b0e7c53207e55958 |
| 출처 메모 | uspto-grants-2004_03 |