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Potassium Carbonate → Methyl 4-([(5-methoxy-5-oxopentyl)[2-({4-[(E)-2-phenylethenyl]benzyl}-oxy)phenethyl]amino}methyl)benzoate

HRID 505616
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HRID 505616 반응식
[OH:1][C:2]1[CH:29]=[CH:28][CH:27]=[CH:26][C:3]=1[CH2:4][CH2:5][N:6]([CH2:15][C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][CH:17]=1)[CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12].Cl[CH2:31][C:32]1[CH:37]=[CH:36][C:35]([CH:38]=[CH:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[CH:34][CH:33]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:14][O:13][C:11](=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][N:6]([CH2:15][C:16]1[CH:17]=[CH:18][C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:24][CH:25]=1)[CH2:5][CH2:4][C:3]1[CH:26]=[CH:27][CH:28]=[CH:29][C:2]=1[O:1][CH2:31][C:32]1[CH:37]=[CH:36][C:35](/[CH:38]=[CH:39]/[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[CH:34][CH:33]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 35309884-ChloromethylstilbeneHCID 11304109Methyl 4-(((2-hydroxyphenethyl)(5-methoxy-5-oxopentyl)amino)methyl)benzoate

생성물 1

HCID 22015012Methyl 4-([(5-methoxy-5-oxopentyl)[2-({4-[(E)-2-phenylethenyl]benzyl}-oxy)phenethyl]amino}methyl)benzoate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1.0 g (2.50 mmol) of methyl 4-{[(2-hydroxyphenethyl)-(5-methoxy-5-oxopentyl)-amino]methyl}benzoate from Ex. I, 0.687 g (3.00 mmol) of 4-(chloromethyl)stilbene and 0.520 g (3.75 mmol) of potassium carbonate in 10.0 ml of acetonitrile are heated at reflux for 18 hours. The solution is filtered and the solvent is distilled off under reduced pressure. The crude product is purified by chromatography over silica gel using the mobile phase cyclohexane/ethyl acetate 4/1.

후처리

  1. temperatureat reflux for 18 hours
  2. filtrationThe solution is filtered
  3. distillationthe solvent is distilled off under reduced pressure
  4. customThe crude product is purified by chromatography over silica gel using the mobile phase cyclohexane/ethyl acetate 4/1

출처 및 근거

ORD 기록
ord-1681b233298f49609a1da3a4ad4e2089
출처 데이터셋
uspto-grants-2010_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07781470B2

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