Methanesulfonyl chloride → N-[2-bromo-5-(trifluoromethyl)phenyl]methanesulfonamide

HRID 505671

반응식

HRID 505671 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:3]=1[NH2:4].[CH3:13][S:14](Cl)(=[O:16])=[O:15]>N1C=CC=CC=1>[Br:1][C:2]1[CH:8]=[CH:7][C:6]([C:9]([F:10])([F:11])[F:12])=[CH:5][C:3]=1[NH:4][S:14]([CH3:13])(=[O:16])=[O:15]

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 679892-Bromo-5-(trifluoromethyl)benzenamine

생성물 1

HCID 59430904N-[2-bromo-5-(trifluoromethyl)phenyl]methanesulfonamide수율 52%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 2-bromo-5-trifluoromethylaniline (3.18 g, 13.25 mmol) in pyridine (18 ml) was added methanesulfonyl chloride (1.03 ml, 13.25 mmol) and the mixture was stirred for 6 hours at room temperature. The solvent was removed in vacuo and the residue was diluted with chloroform. The organic layer was washed with water, 1N hydrochloric acid, a saturated sodium hydrogen carbonate solution and saturated brine and dried over anhydrous sodium sulfate. The solvent was removed in vacuo and the residue was purified by recrystallization to give the subject compound (2.18 g, 52%).

후처리

  1. customThe solvent was removed in vacuo
  2. additionthe residue was diluted with chloroform
  3. washThe organic layer was washed with water, 1N hydrochloric acid
  4. dry with materiala saturated sodium hydrogen carbonate solution and saturated brine and dried over anhydrous sodium sulfate
  5. customThe solvent was removed in vacuo
  6. customthe residue was purified by recrystallization

출처 및 근거

ORD 기록
ord-5888ddb31d474185be9e29694440c5d9
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781479B2

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