Methanol → (R)-2-Hydroxy-1-morpholinopropan-1-one

반응식

[C:1]([O:6]C)(=O)[C@@H:2]([CH3:4])[OH:3].[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.C[O-].[Na+].CO>>[N:8]1([C:1](=[O:6])[C@H:2]([OH:3])[CH3:4])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

참가 물질

반응물 4

HCID 887Methanol

HCID 8083Morpholine

HCID 637514(+)-Methyl lactate

HCID 10942334Sodium Methoxide

생성물 1

HCID 14978393(R)-2-Hydroxy-1-morpholinopropan-1-one

반응 조건

온도: 50 °C

실험 절차

To (R)-methyl lactate (24.42 g, 0.23 mol) were added morphline (21.46 g, 0.25 mol) and sodium methoxide in methanol (14%, 9.04 g, 0.02 mol) and the mixture was stirred for 3 hours at 50° C. After removal of the solvent in vacuo, the residue was subjected to azeotropic distillation three times with toluene to give the subject compound (quant.).

후처리

customAfter removal of the solvent in vacuo
distillationthe residue was subjected to azeotropic distillation three times with toluene
customto give the subject compound (quant.)

출처 및 근거

ORD 기록: ord-e707a0c4b0174d8e9cf946366f8c997f
출처 데이터셋: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07781479B2

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