2-Methyl-1,3-thiazole-5-carbaldehyde → Methyl 6-[(2-methyl-1,3-thiazol-5-yl)methylene]-5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate

반응식

[CH3:1][O:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:11](=[O:15])[CH2:10][CH2:9][CH2:8][C:7]=2[CH:6]=1)=[O:4].[CH3:16][C:17]1[S:18][C:19]([CH:22]=O)=[CH:20][N:21]=1>>[CH3:16][C:17]1[S:18][C:19]([CH:22]=[C:10]2[CH2:9][CH2:8][C:7]3[CH:6]=[C:5]([C:3]([O:2][CH3:1])=[O:4])[CH:14]=[CH:13][C:12]=3[C:11]2=[O:15])=[CH:20][N:21]=1

참가 물질

반응물 2

HCID 139347282-Methyl-1,3-thiazole-5-carbaldehyde

HCID 15309116Methyl 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate

생성물 1

HCID 66722648Methyl 6-[(2-methyl-1,3-thiazol-5-yl)methylene]-5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate수율 60%

실험 절차

The title compound was prepared from 5-oxo-5,6,7,8-tetrahydronaphtalene-2-carboxylic acid methyl ester (396 mg, 1.9 mmol) and 2-methyl-1,3-thiazole-5-carbaldehyde (220 mg, 2.0 mmol) according to Method A3 in 60% yield. ES-MS m/z 314 (M+H)

출처 및 근거

ORD 기록: ord-bf6eb591ea2a403b8dc84e767570ed52
출처 데이터셋: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07781428B2

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