Methanedione--ethanol (1/1) → HCID 59429373, 화합물

HRID 505721노트

반응식

HRID 505721 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:17]([CH:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)[CH:16]3[C:11]([C:12]4[CH:26]=[CH:25][C:24]([C:27]([OH:29])=[O:28])=[CH:23][C:13]=4[CH2:14][CH2:15]3)=[N:10]2)=[CH:5][C:4]=1[CH3:30])#[N:2].C(O)C.C(=O)=O>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C@H:17]([CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)[C@H:16]3[C:11]([C:12]4[CH:26]=[CH:25][C:24]([C:27]([OH:29])=[O:28])=[CH:23][C:13]=4[CH2:14][CH2:15]3)=[N:10]2)=[CH:5][C:4]=1[CH3:30])#[N:2]

참가 물질

3

반응물 2

HCID 19604758Methanedione--ethanol (1/1)2회HCID 249839122-(4-cyano-3-methylphenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid

생성물 1

HCID 59429373HCID 59429373, 화합물

실험 절차

The title compound was prepared from the 2-(4-cyano-3-methylphenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid prepared in Example 21 using chiral resolution (e.g., Method G (Chiralcel OJ-H 30×250 mm; 50% ethanol/carbon dioxide). Second eluting peak: chiral HPLC tR=3.49 minutes (Chiralcel OJ-H 4.6×250 mm; 50% ethanol/carbon dioxide)).

출처 및 근거

ORD 기록
ord-d21d09235e5f45209dcefe43ffad17cd
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781428B2

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