참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tetramethoxypropane | HCID 66019 | — |
| 반응물 | 5-Bromonicotinimidamide | HCID 22735182 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(5-Bromopyridin-3-yl)pyrimidine | HCID 22735178 | 22% |
반응 단계
A mixture of the product of Step B (4.86 g, 20.5 mmol) and 1,1,3,3-tetramethoxypropane (6.59 mL, 40 mmol) in DMF (25 mL) was warmed to 90° C. under N2. After 18 h, the reaction mixture was allowed to cool to 25° C., concentrated in vacuo. Purification of the residue by flash chromatography (EtOAc) afforded the title compound (1.05 g, 22%) as a white solid. MS 237 (M+H)+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06713455B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_03 |
|---|
| ORD ID | ord-7965c9f22cdb4c98b630f5880c75baee |
|---|
| 출처 메모 | uspto-grants-2004_03 |
|---|
