Triethylsilane → methyl 6-cyclohexyl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylate

HRID 505779노트

반응식

HRID 505779 반응식
[C:1]1([C:7]2[C:8]3[S:20][C:19]([C:21]([O:23][CH3:24])=[O:22])=[CH:18][C:9]=3[NH:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.C([SiH](CC)CC)C>C(O)(C(F)(F)F)=O>[CH:1]1([C:7]2[C:8]3[S:20][C:19]([C:21]([O:23][CH3:24])=[O:22])=[CH:18][C:9]=3[NH:10][C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 12052TriethylsilaneHCID 11559121methyl 6-cyclohex-1-en-1-yl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylate

생성물 1

HCID 68467632methyl 6-cyclohexyl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylate수율 95%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

반응 조건

온도
0 °C

실험 절차

A solution (0.1 M) of methyl 6-cyclohex-1-en-1-yl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylate in TFA at 0° C. was treated with triethylsilane (1.5 eq.). The reaction mixture was stirred at 0° C. for 1 h then solvent was evaporated to give the title compound (95%) as a solid.

후처리

  1. customsolvent was evaporated

출처 및 근거

ORD 기록
ord-18e2077e16f34f598996e4aef97bf6c0
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781431B2

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