4-Amino-1-Boc-piperidine → 1,1-Dimethylethyl 4-[({[2-(ethyloxy)-2-oxoethyl]oxy}carbonyl)amino]piperidine-1-carboxylate

HRID 505870

반응식

HRID 505870 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.C1([O:21][C:22]([O:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=O)C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:29]([O:28][C:26](=[O:27])[CH2:25][O:24][C:22]([NH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6][CH2:7]1)=[O:21])[CH3:30]

참가 물질

4

반응물 2

HCID 12682914-Amino-1-Boc-piperidineHCID 12094709Ethyl [(phenoxycarbonyl)oxy]acetate

생성물 1

HCID 684650741,1-Dimethylethyl 4-[({[2-(ethyloxy)-2-oxoethyl]oxy}carbonyl)amino]piperidine-1-carboxylate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A suspension of 5.09 g (25.42 mmol) of 1,1-dimethylethyl 4-aminopiperidine-1-carboxylate and 13.45 g (59.99 mmol) of ethyl [(phenyloxycarbonyl)oxy]acetate (J. Med. Chem., 1999, 42, 277-90) in 300 ml of toluene is heated at reflux for 30 hours.

후처리

  1. temperatureis heated
  2. temperatureat reflux for 30 hours

출처 및 근거

ORD 기록
ord-2370f5c8e8374cbea93b091642512d3f
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781590B2

연결된 노트

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