Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromo-5-fluorotoluene → 4-Fluoro-2-methylbenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromo-5-fluorotoluene | HCID 96743 | — |
| 반응물 | HCID 178418546 | HCID 178418546 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Fluoro-2-methylbenzonitrile | HCID 3826055 | 60% |
반응 단계
A mixture of 2-bromo-5-fluorotoluene (3.5 g, 18.5 mmol) and CuCN (2 g, 22 mmol) in DMF (100 mL) was refluxed for 24 hours. The reaction was diluted with water and extracted with hexane. The organics were dried over MgSO4 and the solvent removed to give product 31 (yield 60%). 1H-NMR (400 MHz, CDCl3): δ 7.60 (dd, J=5.6, 8.8 Hz, 1H), 6.93-7.06 (m, 2H), 2.55 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07781584B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-13bb36c7418b4e5d806a5cdd5847ab70 |
| 출처 메모 | uspto-grants-2010_08 |