Water → HCID 59431290, 화합물

HRID 505930노트

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HRID 505930 반응식
O.C(=O)([O-])[O-].[K+].[K+].Br[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11].[CH3:15][C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[C:22]([N+:25]([O-:27])=[O:26])[CH:21]=[CH:20][CH:19]=2>C(#N)C>[N+:25]([C:22]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:23]=1[CH:24]=[C:16]([CH3:15])[N:17]2[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])([O-:27])=[O:26]

참가 물질

6

반응물 4

HCID 962Water2회HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 110951501H-Indole, 2-methyl-4-nitro-

생성물 1

HCID 59431290HCID 59431290, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
60 °C

실험 절차

Water (4.5 ml), potassium carbonate (25.9 g, 187 mmol) and ethyl bromoacetate (20.8 ml, 188 mmol) were added sequentially to a suspension of 2-methyl-4-nitro-1H-indole (30 g, 170 mmol) in acetonitrile (225 ml) and the mixture heated at 60° C. for 16 hours. After allowing to cool to ambient temperature, water (225 ml) was added and the resulting mixture was broken up and then filtered. The solid was washed with water (2×75 ml), followed by IMS (2×75 ml) then dried in a vacuum oven to give (4-nitro-2-methyl-1H-indol-1-yl)-acetic acid, ethyl ester, 32.15 g (72%).

후처리

  1. temperatureto cool to ambient temperature
  2. filtrationfiltered
  3. washThe solid was washed with water (2×75 ml)
  4. customthen dried in a vacuum oven

출처 및 근거

ORD 기록
ord-c3e1204296334c9ca75287e0612d163f
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781598B2

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