1-(6-Nitroindolin-1-yl)ethanone → 1-Acetyl-6-aminoindoline

HRID 506078

반응식

HRID 506078 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([N+:13]([O-])=O)[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>CCOC(C)=O.[Pd]>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([NH2:13])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 2585661-(6-Nitroindolin-1-yl)ethanone

생성물 1

HCID 2585641-Acetyl-6-aminoindoline수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

1-Acetyl-6-nitroindoline (3.8 g, 18.3 mmol) is suspended in EtOAc (200 mL). Pd/C (650 mg, 10%) is added, and the mixture is hydrogenated at 40-55 p.si.i. for 2 hours. The mixture is then filtered through celite. The filtrate is concentrated, and the residue is triturated with ether to yield 1-acetyl-6-aminoindoline (3.18 g, 99%) as an orange solid.

후처리

  1. filtrationThe mixture is then filtered through celite
  2. concentrationThe filtrate is concentrated
  3. customthe residue is triturated with ether

출처 및 근거

ORD 기록
ord-07058c0a5b194461861993e1f8fdbab0
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781478B2

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