Acetonitrile → 1-Naphthalenesulfonylaminoethylthioethylamine

HRID 50610

반응식

HRID 50610 반응식
N[CH2:2][CH2:3][S:4][CH2:5][CH2:6][NH2:7].[C:8]1([S:18](Cl)(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1.C(#[N:24])C>>[C:8]1([S:18]([NH:24][CH:3]([S:4][CH2:5][CH2:6][NH2:7])[CH3:2])(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 3

HCID 6342AcetonitrileHCID 665601-Naphthalenesulfonyl chlorideHCID 700962,2'-Thiobis(ethanamine)

생성물 1

HCID 698871031-Naphthalenesulfonylaminoethylthioethylamine

실험 절차

Under ice cooling, 5.29 g of aminoethylthioethylamine was added dropwise with 120 mL of acetonitrile solution in which 1.00 g of 1-naphthalenesulfonyl chloride was dissolved, and the mixture was stirred at room temperature for two days. The reaction mixture was evaporated under reduced pressure, and then the residue was added with 500 mL of water and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure to obtain 1.50 g of 1-naphthalenesulfonylaminoethylthioethylamine.

후처리

  1. dissolutionwas dissolved
  2. customThe reaction mixture was evaporated under reduced pressure
  3. additionthe residue was added with 500 mL of water
  4. extractionextracted with dichloromethane
  5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  6. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-85c61463f18548a999ef56fba6e12601
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713473B1

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