Cadaverine → N-(5-aminopentyl)naphthalene-1-sulfonamide

HRID 50611

반응식

HRID 50611 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[C:8]1([S:18](Cl)(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1>C(#N)C>[C:8]1([S:18]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7])(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 273CadaverineHCID 665601-Naphthalenesulfonyl chloride

생성물 1

HCID 4303N-(5-aminopentyl)naphthalene-1-sulfonamide수율 84.2%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Under ice cooling, 7.91 g of 1,5-diaminopentane was added dropwise with 240 mL of acetonitrile solution in which 1.75 g of 1-naphthalenesulfonyl chloride was dissolved, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was evaporated under reduced pressure, and the residue was added with 500 mL of water and extracted with dichloromethane. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain 1.90 g of 5-(1-naphthalenesulfonyl)aminopentylamine.

후처리

  1. dissolutionwas dissolved
  2. customThe reaction mixture was evaporated under reduced pressure
  3. additionthe residue was added with 500 mL of water
  4. extractionextracted with dichloromethane
  5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e8b2e0abf9594c33858deb2304f39cd4
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713473B1

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