Toluene → 9-Ethyl-5-ethoxycarbazole-6-carboxylic acid

HRID 50612

반응식

HRID 50612 반응식
C(O[C:4]1[CH:16]=[C:15]2[C:7]([C:8]3[CH2:9][CH2:10][CH2:11][CH2:12][C:13]=3[NH:14]2)=[CH:6][C:5]=1[C:17]([OH:19])=[O:18])C.C1(Cl)C(=O)C(Cl)=C(Cl)[C:22](=[O:23])[C:21]=1Cl.[C:32]1(C)C=CC=C[CH:33]=1>>[CH2:32]([N:14]1[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[C:7]2[C:15]1=[CH:16][CH:4]=[C:5]([C:17]([OH:19])=[O:18])[C:6]=2[O:23][CH2:22][CH3:21])[CH3:33]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 8371ChloranilHCID 698875637-Ethoxytetrahydrocarbazole-6-carboxylic acid

생성물 1

HCID 227361469-Ethyl-5-ethoxycarbazole-6-carboxylic acid

실험 절차

The 7-ethoxytetrahydrocarbazole-6-carboxylic acid obtained in Example 37 was dissolved in 8 mL of toluene, and the solution was added with 2.14 g of chloranil and refluxed for 2 hours and 30 minutes. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (ethyl acetate) to obtain 336 mg of 9-ethyl-5-ethoxycarbazole-6-carboxylic acid. Compound 1-38 was obtained in the same manner as in Example 36 except that the 9-ethyl-5-ethoxycarbazole-6-carboxylic acid obtained was used.

후처리

  1. temperaturerefluxed for 2 hours and 30 minutes
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. custompurified by silica gel column chromatography (ethyl acetate)

출처 및 근거

ORD 기록
ord-bf84dbc72e724a1cb63717346ff96827
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713473B1

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