Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 506170생성일: 2026년 10월 27일
3-Oxobutyronitrile → 5-(Dimethylamino)-2-(dimethylaminomethylidene)-3-oxopent-4-enenitrile
https://huagongshe.com/reaction/506170
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Oxobutyronitrile | HCID 75579 | — |
| 반응물 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 반응물 | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| 생성물 | 5-(Dimethylamino)-2-(dimethylaminomethylidene)-3-oxopent-4-enenitrile | HCID 72297055 | 67.5% |
반응 단계
A mixture of acetoacetonitrile (41 g, 493 mmol), t-butoxybis(dimethyl amino)methane (86 g, 493 mmol) and DMF-DMA (263 mL, 1.97 mol) was heated at 100° C. overnight and evaporated to remove the volatiles. The residue was triturated with hexanes/ether (1:1) and the solids were collected by filtration and washed with hexanes/ether (1:1) and a minimum amount of EtOAc to give 64.3 g (67%) of 5-(dimethylamino)-2-[(dimethylamino)methylene]-3-oxopent-4-enenitrile as a light yellow solid, which was used for the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07781591B2 |
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| 출처 데이터셋 | uspto-grants-2010_08 |
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| ORD ID | ord-c6005b4fad4544b394938890aa4465f5 |
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| 출처 메모 | uspto-grants-2010_08 |
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