2,4,5-Trimethylpyridine → Benzofuran-5-ol

HRID 506186

반응식

C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][CH:9]=[CH:8][C:7]=2[CH:11]=1.N1C=C(C)C(C)=CC=1C.[Li+].[I-]>>[O:10]1[C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[CH:11][C:7]=2[CH:8]=[CH:9]1

참가 물질

반응물 3

HCID 142802,4,5-Trimethylpyridine

HCID 259435-Methoxybenzofuran

HCID 66321Lithium iodide

생성물 1

HCID 11651159Benzofuran-5-ol

실험 절차

5-Methoxybenzofuran was treated with 2,4,5-collidine and LiI at 170° C. to provide benzofuran-5-ol, which was reacted with 2-chloroethyl-p-toluenesulfonate and Cs2CO3 to give 5-(2-chloroethoxy)-1-benzofuran.

출처 및 근거

ORD 기록: ord-2060e06ae984460ca08857a73c4aef75
출처 데이터셋: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07781591B2

연결된 노트

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