1-(2-Methoxyphenyl)piperazine → [1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]piperidin-1-yl}-methanone

To a solution of 2 (1.0 g, 2.60 mmol) in acetonitrile (25 mL) was added 1-(2-methoxyphenyl)piperazine (0.55 g, 2.86 mmol) and triethylamine (2 mL). The reaction was stirred and refluxed for 20 h. After cooling to room temperature, most of solvent was removed by rotary evaporation. The reaction mixture was partitioned between dichloromethane and water (50 mL each), and the organic layer was washed with sat. sodium carbonate (50 mL) and water. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated by rotary evaporation. The organic residue was purified by flash chromatography on silica gel, eluting with dichloromethane/2.0 M ammonia in ethyl alcohol (96:4) to give 3 (0.54 g, 43%) as a light brown solid; C28H36ClN3O2, LRMS (m/z)=483 (MH+).

1. temperaturerefluxed for 20 h
2. customwas removed by rotary evaporation
3. customThe reaction mixture was partitioned between dichloromethane and water (50 mL each)
4. washthe organic layer was washed with sat. sodium carbonate (50 mL) and water
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated by rotary evaporation
8. customThe organic residue was purified by flash chromatography on silica gel
9. washeluting with dichloromethane/2.0 M ammonia in ethyl alcohol (96:4)

ORD 기록

ord-126b512605ac405ea8a83500c878b631

출처 데이터셋

uspto-grants-2004_03

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06713479B2