Triethylamine → HCID 59432150, 화합물

HRID 506489

반응식

HRID 506489 반응식
[NH2:1][CH:2]([CH:8]([OH:13])[C:9]([F:12])([F:11])[F:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[F:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[C:17]([C:24]([F:27])([F:26])[F:25])[CH:16]=1.C(N(CC)CC)C>C1COCC1>[F:12][C:9]([F:10])([F:11])[CH:8]([OH:13])[CH:2]([NH:1][C:19](=[O:20])[C:18]1[CH:22]=[CH:23][C:15]([F:14])=[CH:16][C:17]=1[C:24]([F:27])([F:25])[F:26])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 6882554-Fluoro-2-(trifluoromethyl)benzoic acidHCID 15634552HCID 15634552, 화합물

생성물 1

HCID 59432150HCID 59432150, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1.7 g (8.5 mmol) of ethyl 2-amino-4,4,4-trifluoro-3-hydroxybutyrate were dissolved in THF, and initially 1.8 g of 4-fluoro-2-trifluoromethylbenzoic acid and 2.6 g (25.4 mmol) of triethylamine and then, at 5° C., 1.9 g (8.5 mmol) of bis(2-oxo-3-oxazolinidylphosphoryl chloride were added. The mixture was stirred at RT for 16 h. The reaction solution was then concentrated, and the residue was diluted with water and extracted with ethyl acetate. The combined organic phases were dried and the solvent was removed. This gave 3.1 g (93% of theory) of the title compound as a colorless residue.

후처리

  1. concentrationThe reaction solution was then concentrated
  2. additionthe residue was diluted with water
  3. extractionextracted with ethyl acetate
  4. customThe combined organic phases were dried
  5. customthe solvent was removed

출처 및 근거

ORD 기록
ord-a1eb04bf736d47c4a21d42c4c66297f6
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786046B2

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