Triethylamine → 1-(5-Nitropyridin-2-yl)azetidin-3-ol

반응식

Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.Cl.[NH:12]1[CH2:15][CH:14]([OH:16])[CH2:13]1.C(N(CC)CC)C>>[OH:16][CH:14]1[CH2:15][N:12]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=2)[CH2:13]1

참가 물질

반응물 3

HCID 8471Triethylamine

HCID 783082-Chloro-5-nitropyridine

HCID 27592903-Hydroxyazetidine hydrochloride

생성물 1

HCID 529372641-(5-Nitropyridin-2-yl)azetidin-3-ol수율 95.7%

실험 절차

The process is carried out according to the method described in step 5.1, using 7 g (42.83 mmol) of 2-chloro-5-nitropyridine and 5.75 g (51.4 mmol) of 3-azetidinol hydrochloride. In this case, 13 g (128.45 mmol) of triethylamine are also added. 8 g of the expected product are thus isolated.

출처 및 근거

ORD 기록: ord-53756dc0e3634078b643de2e7cd96c7f
출처 데이터셋: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07786104B2

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