HCID 13292919, 화합물 → HCID 178452909, 화합물

HRID 506587노트

반응식

HRID 506587 반응식
[C:1]1([C:7]2[NH:16][C:10]3=[N:11][CH:12]=[C:13]([NH2:15])[CH:14]=[C:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:18]([O:20][CH:21]([CH:23]=[CH2:24])[CH3:22])=[O:19]>N1C=CC=CC=1.ClCCl.O>[CH3:22][CH:21]([O:20][C:18](=[O:19])[NH:15][C:13]1[CH:14]=[C:9]2[N:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[NH:16][C:10]2=[N:11][CH:12]=1)[CH:23]=[CH2:24]

참가 물질

6

반응물 2

HCID 13292919HCID 13292919, 화합물HCID 178508009HCID 178508009, 화합물

생성물 1

HCID 178452909HCID 178452909, 화합물

시약·촉매·용매 3

HCID 962Water용매HCID 1049Pyridine용매HCID 6344Dichloromethane용매

실험 절차

80 mg 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine (0.38 mmol,) in 3 ml dry pyridine were treated with a solution of 3-buten-2-yl chloroformate in dichloromethane. The mixture was stirred at room temperature over night, diluted with 1 ml water and stirred for another hr. The solvents were evaporated and the residue was dispersed in water with sonication, filtered, and the filter residue washed thoroughly with water and ether.

후처리

  1. stirringstirred for another hr
  2. customThe solvents were evaporated
  3. additionthe residue was dispersed in water with sonication
  4. filtrationfiltered
  5. washthe filter residue washed thoroughly with water and ether

출처 및 근거

ORD 기록
ord-fc08b83e49d7436fb938071f3c630d09
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786113B2

반응 노트

불러오는 중…