Water → HCID 178447164, 화합물

HRID 506588노트

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HRID 506588 반응식
[CH3:1][CH:2]([OH:6])[CH:3]=[CH:4][CH3:5].[C:7](N1C=CN=C1)(N1C=CN=C1)=[O:8].[C:19]1([C:25]2[NH:34][C:28]3=[N:29][CH:30]=[C:31]([NH2:33])[CH:32]=[C:27]3[N:26]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>ClCCl.CN1CCCC1=O>[CH3:1][CH:2]([O:6][C:7](=[O:8])[NH:33][C:31]1[CH:32]=[C:27]2[N:26]=[C:25]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[NH:34][C:28]2=[N:29][CH:30]=1)/[CH:3]=[CH:4]/[CH3:5]

참가 물질

7

반응물 4

HCID 962WaterHCID 15289(+-)-3-Penten-2-olHCID 682631,1'-CarbonyldiimidazoleHCID 178508009HCID 178508009, 화합물

생성물 1

HCID 178447164HCID 178447164, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 13387N-methyl-2-pyrrolidone용매

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온도
0 °C

실험 절차

32 mg 3-penten-2-ol (0.38 mmol,) in 1 ml dry dichloromethane were treated at 0° C. with 62 mg 1,1′-carbonyl-diimidazole. The mixture was stirred at 0° C. for 2 hrs. 80 mg 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine (0.38 mmol,) in 0.5 ml N-methylpyrrolidone (NMP) were added and the mixture stirred over night at room temperature. 1 ml water was added, the precipitate filtered, and the filter residue washed thoroughly with water and ether and further purified by chromatography.

후처리

  1. stirringthe mixture stirred over night at room temperature
  2. filtrationthe precipitate filtered
  3. washthe filter residue washed thoroughly with water and ether
  4. customfurther purified by chromatography

출처 및 근거

ORD 기록
ord-41505af1f0fc4283913024858fe5251c
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786113B2

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