2,5-Dimethylpyrrolidine, (2R,5R)- → 8-(3-((2S,5S)-2,5-dimethylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one

HRID 506650

반응식

HRID 506650 반응식
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:19]=[CH:18][C:17]3[N:16]4[CH2:20][CH2:21][NH:22][C:23](=[O:24])[C:15]4=[CH:14][C:13]=3[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:25][C@H]1N[C@H](C)CC1>>[CH3:6][C@H:5]1[CH2:4][CH2:3][C@H:2]([CH3:25])[N:1]1[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:19]=[CH:18][C:17]2[N:16]3[CH2:20][CH2:21][NH:22][C:23](=[O:24])[C:15]3=[CH:14][C:13]=2[CH:12]=1

참가 물질

3

반응물 2

HCID 6417672,5-Dimethylpyrrolidine, (2R,5R)-HCID 166795198-(3-(piperidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one

생성물 1

HCID 166796118-(3-((2S,5S)-2,5-dimethylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one수율 7%

실험 절차

The title compound was synthesized in analogy to example 2, from 8-(3-chloro-propoxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 2, intermediate) and (2R,5R)-(−)-trans-2,5-dimethylpyrrolidine (commercially available), to give the desired product as a white solid (7%).

출처 및 근거

ORD 기록
ord-224bb1ff10e84f6188682ba4ecac6627
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786109B2

연결된 노트

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