4-Morpholinobenzylamine → HCID 68468333, 화합물

HRID 506807

반응식

HRID 506807 반응식
[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[N:23]([S:24]([C:27]4[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][CH:28]=4)(=[O:26])=[O:25])[C:16]4[N:17]=[CH:18][CH:19]=[C:20]([CH:21]=O)[C:15]=4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:34][CH3:35].[O:36]1[CH2:41][CH2:40][N:39]([C:42]2[CH:49]=[CH:48][C:45]([CH2:46][NH2:47])=[CH:44][CH:43]=2)[CH2:38][CH2:37]1>>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[C:9]([C:13]3[N:23]([S:24]([C:27]4[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][CH:28]=4)(=[O:26])=[O:25])[C:16]4=[N:17][CH:18]=[CH:19][C:20]([CH2:21][NH:47][CH2:46][C:45]5[CH:44]=[CH:43][C:42]([N:39]6[CH2:40][CH2:41][O:36][CH2:37][CH2:38]6)=[CH:49][CH:48]=5)=[C:15]4[CH:14]=3)=[CH:10][N:11]([CH3:12])[C:6]2=[CH:5][C:4]=1[O:34][CH3:35]

참가 물질

3

반응물 2

HCID 27764584-MorpholinobenzylamineHCID 86618635HCID 86618635, 화합물

생성물 1

HCID 68468333HCID 68468333, 화합물

실험 절차

The product is prepared by following the procedure described in example 34, stage (j) starting with 0.1 g of 2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-carbaldehyde and 0.196 cm3 of 4-morpholinobenzylamine instead of the cyclopropylamine used in example 34, stage (j). After purification by flash-pack chromatography (SiO2, dichloromethane/methanol 98/2 by volume as eluents), 0.031 g of [2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-(4-morpholin-4-yl-benzyl)amine is obtained with the following characteristics:

후처리

  1. customThe product is prepared
  2. customAfter purification by flash-pack chromatography (SiO2, dichloromethane/methanol 98/2 by volume as eluents)

출처 및 근거

ORD 기록
ord-76aaa0e31807455c89f83c7bb0acde42
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786114B2

연결된 노트

불러오는 중…