2-Amino-5-bromobenzonitrile → 4-Amino-3'-chloro-biphenyl-3-carbonitrile

HRID 50689

반응식

HRID 50689 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:7](Br)=[CH:6][C:3]=1[C:4]#[N:5].[Cl:11][C:12]1[CH:13]=[C:14](B(O)O)[CH:15]=[CH:16][CH:17]=1>>[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:11])[CH:17]=2)=[CH:6][C:3]=1[C:4]#[N:5]

참가 물질

3

반응물 2

HCID 4297402-Amino-5-bromobenzonitrileHCID 2734323(3-Chlorophenyl)boronic acid

생성물 1

HCID 97945754-Amino-3'-chloro-biphenyl-3-carbonitrile

실험 절차

Prepared from 2-amino-5-bromobenzonitrile and 3-chlorophenyl boronic acid according to procedure A. Off-white solid: mp 118-119° C.; 1H-NMR (DMSO-d6) δ 7.80 (d, 1H, J=2.3 Hz), 7.65-7.72 (m, 2H), 7.57 (d, 1H, J=8.0 Hz), 7.42 (t, 1H, J=7.9 Hz), 7.31 (m, 1H), 6.87 (d, 1H, J=8.7 Hz), 6.29 (br, 2H); Anal. Calc. For C13H9ClN2: C, 68.28; H, 3.97; N, 12.25: Found: C, 67.68; H, 4.06; N, 11.89.

출처 및 근거

ORD 기록
ord-f17ec43979814d23a9c8313a282a3f22
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713478B2

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