참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Chloral Hydrate | HCID 2707 | — |
| 반응물 | Sodium Sulfate | HCID 24436 | — |
| 반응물 | 4-Aminoindan | HCID 122569 | — |
| 반응물 | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Hydroxyimino-N-indan-4-yl-acetamide | HCID 72740628 | 90.4% |
반응 단계
To a solution of chloral hydrate (5.46 g, 33 mmol) and anhydrous sodium sulfate (25.6 g, 180 mmol) in water (92 mL) add a mixture of hydroxylamine sulfate (25.6 g, 156 mmol), 4-aminoindane (4 g, 30 mmol), concentrated hydrochloric acid (3.1 mL) in water (30.8 mL). Heat the mixture up to 45° C. for 90 min, to 52° C. over 45 min and to 75° C. for 60 min. Cool the mixture to room temperature and filter the solid. Wash the solid with water and hexane. Dry the solid under vacuum to yield the title compound (5.54 g, 90%). MS (ES−): 203 (M−H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07786108B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_08 |
|---|
| ORD ID | ord-5698eb4ae42646b0a98745a51caaad1c |
|---|
| 출처 메모 | uspto-grants-2010_08 |
|---|
