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Diisopropylcarbodiimide → 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid (3-butoxy-propyl)-amide

HRID 507196
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HRID 507196 반응식
[O:1]([CH2:8][C:9]1[N:13]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)[C:12]2[CH:26]=[CH:27][C:28]([C:30](O)=[O:31])=[CH:29][C:11]=2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC(C)N=C=NC(C)C.[CH2:42]([O:46][CH2:47][CH2:48][CH2:49][NH2:50])[CH2:43][CH2:44][CH3:45]>C1COCC1>[CH2:42]([O:46][CH2:47][CH2:48][CH2:49][NH:50][C:30]([C:28]1[CH:27]=[CH:26][C:12]2[N:13]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[C:9]([CH2:8][O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[N:10][C:11]=2[CH:29]=1)=[O:31])[CH2:43][CH2:44][CH3:45]
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참가 물질

5

반응물 3

HCID 12734DiisopropylcarbodiimideHCID 854611-Propanamine, 3-butoxy-HCID 684638462-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid

생성물 1

HCID 693886092-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid (3-butoxy-propyl)-amide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran
용매

실험 절차

0.16 mmol of 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid were dissolved in 1 ml THF with 1 eq. DIC. After 15 min 1.5 eq of 3-butoxypropylamine were added and the reaction stirred at room temperature for 16 h. The crude material was purified via reversed phase preparative HPLC. MS(ISP): 556.3 (M+H)+.

후처리

  1. customThe crude material was purified via reversed phase preparative HPLC

출처 및 근거

ORD 기록
ord-b991c5ff44be4d95a14d6e5009fe3f4a
출처 데이터셋
uspto-grants-2010_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07786128B2

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