Cesium carbonate → 3-(3-Chloro-2-methyl-phenyl)-1-(2-pyrazolo[3,4-b]pyridin-1-yl-acetyl)-imidazolidin-4-one

HRID 507388노트

반응식

HRID 507388 반응식
Cl[CH2:2][C:3]([N:5]1[CH2:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[C:12]=2[CH3:18])[CH2:6]1)=[O:4].[NH:19]1[C:23]2=[N:24][CH:25]=[CH:26][CH:27]=[C:22]2[CH:21]=[N:20]1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C.C(OCC)(=O)C>[Cl:17][C:13]1[C:12]([CH3:18])=[C:11]([N:7]2[C:8](=[O:10])[CH2:9][N:5]([C:3](=[O:4])[CH2:2][N:19]3[C:23]4=[N:24][CH:25]=[CH:26][CH:27]=[C:22]4[CH:21]=[N:20]3)[CH2:6]2)[CH:16]=[CH:15][CH:14]=1

참가 물질

6

반응물 3

HCID 10796Cesium carbonateHCID 27558501H-pyrazolo(3,4-b)pyridineHCID 594340271-(2-Chloro-acetyl)-3-(3-chloro-2-methyl-phenyl)-imidazolidin-4-one

생성물 1

HCID 594340293-(3-Chloro-2-methyl-phenyl)-1-(2-pyrazolo[3,4-b]pyridin-1-yl-acetyl)-imidazolidin-4-one

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 1-(2-Chloro-acetyl)-3-(3-chloro-2-methyl-phenyl)-imidazolidin-4-one (230 mg, 0.8 mmol, 1 eq), 1H-Pyrazolo[3,4-b]pyridine (96 mg, 0.8 mmol, 1 eq), Cesium carbonate (653 mg, 2.0 mmol, 2.5 eq) in DMF (6 ml) was stirred at room temperature overnight. It was diluted with ethyl acetate, washed with water and purified with HPLC to give the desired product. LCMS observed for (M+H)+: 370.1

후처리

  1. washwashed with water
  2. custompurified with HPLC

출처 및 근거

ORD 기록
ord-1c490ec9cd434522aebc6fdfc121abb9
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786157B2

반응 노트

불러오는 중…