Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 507402생성일: 2026년 10월 24일
Stannous chloride dihydrate → 3-[2-(4-Amino-phenyl)-ethyl]-2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one
https://huagongshe.com/ko/reaction/507402
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Stannous chloride dihydrate | HCID 61436 | — |
| 반응물 | 2-Methyl-3-[2-(4-nitro-phenyl)-ethyl]-5,5-diphenyl-3,5-dihydro-imidazol-4-one | HCID 68466653 | — |
| 용매 | Ammonia | HCID 222 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-[2-(4-Amino-phenyl)-ethyl]-2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one | HCID 68466411 | 97.4% |
반응 단계
A mixture of 2-methyl-3-[2-(4-nitro-phenyl)-ethyl]-5,5-diphenyl-3,5-dihydro-imidazol-4-one (205 mg, 0.5 mmol) and SnCl2.2H2O (591 mg, 2.6 mmol) in 10 mL ethanol is heated to 50° C. for 5 hours. The reaction mixture is cooled to room temperature, diluted with water and aqueous ammonia is added to reach pH 8-9. The mixture is filtered, the filtrate evaporated and the residue purified by flash chromatography. ISCO Companion CombiFlash, 12 g silica gel, methylene chloride/ethanol to yield 3-[2-(4-amino-phenyl)-ethyl]-2-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one (180 mg, 85%). LC/MS at 254 nm; [M+H] 370; Rt 2.424 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07786155B2 |
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| 출처 데이터셋 | uspto-grants-2010_08 |
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| ORD ID | ord-9d83dfe6cfc74659985b6b1d82a5ff24 |
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| 출처 메모 | uspto-grants-2010_08 |
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