Trifluoroacetic acid → 1-(2-Amino-ethyl)-5,5-dimethyl-imidazolidin-2-one
반응식
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[C:14]([CH3:16])([CH3:15])[CH2:13][NH:12][C:11]1=[O:17])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][CH2:9][N:10]1[C:14]([CH3:15])([CH3:16])[CH2:13][NH:12][C:11]1=[O:17]참가 물질
4
실험 절차
[2-(5,5-Dimethyl-2-oxo-imidazolidin-1-yl)-ethyl]-carbamic acid tert-butyl ester (450 mg, 1.75 mmol) was dissolved in DCM (5 mL) and TFA (1 mL) was added. The mixture was allowed to stand for 16 h, concentrated, and purifed by SCX ion exchange chromatography to give the product as a yellow oil (256 mg, 93%).
후처리
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-a35f980edc084a6f95f4abb273fa71f4
- 출처 데이터셋
- uspto-grants-2010_08
- 특허 번호
- US07786132B2
반응 노트
불러오는 중…