Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromothiazole → Thiazole, 2-(phenylthio)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromothiazole | HCID 76430 | — |
| 반응물 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 반응물 | Sodium benzenethiolate | HCID 4110039 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Thiazole, 2-(phenylthio)- | HCID 606073 | — |
반응 단계
A solution of sodium thiophenolate (0.61 g, 4.62 mmol) and 2-bromothiazole (0.38 mL, 4.2 mmol) in 20 mL of toluene was treated with 0.19 g (0.21 mmol) of Pd2dba3 and 0.12 g (0.21 mmol) of Xantphos and heated at reflux for 10 min. The crude solution was concentrated onto 5 g of silica gel and then purified by flash chromatography to give the title compound. MS (M+H)+ 194.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07786132B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-f4267e351f8b497abbac57e4cfc78fa0 |
| 출처 메모 | uspto-grants-2010_08 |