Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-1,1-dimethoxyethane → 2-(N-Methyl-N-phenylamino)thiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-1,1-dimethoxyethane | HCID 60986 | — |
| 반응물 | 1-Methyl-1-phenylthiourea | HCID 723631 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-(N-Methyl-N-phenylamino)thiazole | HCID 23459375 | — |
반응 단계
A solution of 10 g (60 mmol) of N-methyl-N-phenylthiourea in 100 mL of toluene was treated with 7.2 mL (63 mmol) of chloroacetaldehyde dimethylacetal and heated at reflux for 12 h. The solvent was removed in vacuo and the residue purified by flash chromatography eluting with a linear gradient of 30% EtOAc in hexane to 80% EtOAc in hexane to deliver the title compound. MS (M+H)+ 191.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07786132B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-02e610bd787749ae9e8cb99fa034b663 |
| 출처 메모 | uspto-grants-2010_08 |