Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 4-Aminonicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 4-{[(Tert-butoxy)carbonyl]amino}pyridine-3-carboxylic acid | HCID 22172623 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Aminonicotinic acid | HCID 319979 | — |
반응 단계
A mixture of 4-(N-t-butoxycarbonylamino)nicotinic acid (2.72 g, 11.4 mmol), TFA (10 mL), and CH2Cl2 (20 mL) is stirred at room temperature for 12 h. The volatiles are removed under reduced pressure, and the resulting crude 4-amino nicotinic acid is used directly in the next reaction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713484B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-9e3cbd9745244c5e825a237891073967 |
| 출처 메모 | uspto-grants-2004_03 |