4-Methylpiperazine-1-carbonyl chloride monohydrochloride → Zopiclone

HRID 507800

반응식

HRID 507800 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:16]([OH:17])[C:15]3[C:10](=[N:11][CH:12]=[CH:13][N:14]=3)[C:9]2=[O:18])=[N:6][CH:7]=1.Cl.Cl[C:21]([N:23]1[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]1)=[O:22]>C(N(CC)CC)C>[CH3:29][N:26]1[CH2:27][CH2:28][N:23]([C:21]([O:18][CH:9]2[N:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=3)[C:16](=[O:17])[C:15]3[N:14]=[CH:13][CH:12]=[N:11][C:10]2=3)=[O:22])[CH2:24][CH2:25]1

참가 물질

4

반응물 2

HCID 30169344-Methylpiperazine-1-carbonyl chloride monohydrochlorideHCID 64519726-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo(3,4-b)pyrazin-5-one

생성물 1

HCID 5735Zopiclone

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

reacting 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]pyrazine with 1-chlorocarbonyl-4-methylpiperazine hydrochloride in an organic solvent in presence of triethyl amine along with a catalytic amount of an acylation catalyst to obtain racemic zopiclone;

출처 및 근거

ORD 기록
ord-5e07df90252647c8bf03cbfce42e4c2c
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786304B2

연결된 노트

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