Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-5-chloropyridine → 3-(5-Chloropyrid-2-yl)carbamoylpyrazine-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-5-chloropyridine | HCID 66174 | — |
| 반응물 | Furo(3,4-b)pyrazine-5,7-dione | HCID 78482 | — |
| 생성물 | 3-(5-Chloropyrid-2-yl)carbamoylpyrazine-2-carboxylic acid | HCID 3280818 | 85% |
반응 단계
The addition of 2-amino-5-chloropyridine to pyrazine 2,3-dicarboxylic acid anhydride (II) in a lot wise manner at room temperature in a molar ratio of 1.05:1 surprisingly accelerates the reaction to completion in resulting the product, 3-(5-chloropyrid-2-yl)carbamoyl-pyrazine-2-carboxylic acid (III) having high purity (>99%) with a good yield of 85 to 90% when compared with the prior art processes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07786304B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-f02e56f6fbad4c4a87ecdbf8dca27859 |
| 출처 메모 | uspto-grants-2010_08 |