Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-(3-Methylbutyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Bromo-4'-(trifluoromethyl)acetophenone | HCID 321979 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | (3-Methyl-butyl)-thiourea | HCID 2459097 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-(3-Methylbutyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine | HCID 23143261 | 27.3% |
반응 단계
A solution of N-(3-methylbutyl)thiourea (3.00 g, 20.5 mmol), 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone (5.45 g, 20.5 mmol), sodium acetate (2.19 g, 26.7 mmol) in ethanol (50 mL) was stirred at 90° C. for 4 hr. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained solid was recrystallized from dichloromethane-hexane to give the title compound (1.76 g, yield 27%) as pale-yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07786165B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-17451a31c1a242d2998f0b1a7f9c5bc1 |
| 출처 메모 | uspto-grants-2010_08 |