Thionyl Chloride → 4-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazole

HRID 508165노트

반응식

HRID 508165 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][CH:11]=[N:10][C:9]=2[CH2:13]O)=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>>[Cl:17][CH2:13][C:9]1[N:10]=[CH:11][O:12][C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 58284362[5-(4-Chlorophenyl)-1,3-oxazol-4-yl]methanol

생성물 1

HCID 582842644-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazole

실험 절차

269 mg (0.77 mmol) of the compound from Example 38A are initially charged in 0.43 ml (5.85 mmol) of thionyl chloride. The reaction mixture is stirred at RT for 12 h, and excess thionyl chloride is then removed under reduced pressure. The residue is taken up in 5 ml of ethyl acetate and washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reactions.

후처리

  1. customexcess thionyl chloride is then removed under reduced pressure
  2. washwashed once with 2 ml of sat. aqueous sodium bicarbonate solution
  3. dry with materialThe organic phase is dried over magnesium sulfate
  4. customthe solvent is removed on a rotary evaporator
  5. customThe product obtained
  6. customis used without further purification in the subsequent reactions

출처 및 근거

ORD 기록
ord-73aa8356cf0b45e293dc9bff575be878
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09095582B2

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