Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 57493916, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2,5-Hexanedione | HCID 8035 | — |
| 반응물 | 2-Benzothiazolamine, 6-bromo- | HCID 85149 | — |
| 반응물 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | HCID 57493916 | HCID 57493916 | 84% |
반응 단계
A solution 6-bromobenzo[d]thiazol-2-amine (5.75 g, 25.1 mmol), hexane-2,5-dione (2.95 mL, 25.1 mmol), and PPTS (0.95 g, 3.76 mmol) in benzene (100 ml) was refluxed for 16 h while water was removed with a Dean-Stark trap. The cooled mixture was poured into EtOAc (100 mL) and extracted with saturated aq. NaHCO3 (2×100 mL) and brine. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo. The crude product was purified by column chromatography on silica gel using 9:1 EtOAc:hexanes as the eluent to give the title compound as an orange oil (6.46 g, 84%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09095590B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-820f38f64ed24e64920365a25f92ae34 |
| 출처 메모 | uspto-grants-2015_08 |