Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methyl-2-pentene → 5-bromo-2,3-dihydro-1H-indene-1-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methyl-2-pentene | HCID 12243 | — |
| 반응물 | Sodium Chlorite | HCID 23668197 | — |
| 반응물 | Monosodium phosphate | HCID 23672064 | — |
| 반응물 | (E)-5-bromo-1-(methoxymethylene)-2,3-dihydro-1H-indene | HCID 58909702 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | tert-Butanol | HCID 6386 | — |
| 생성물 | 5-bromo-2,3-dihydro-1H-indene-1-carboxylic acid | HCID 13840006 | 56% |
반응 단계
To a solution of the product from Example 100, Part B (300 mg, 1.3 mmol) and 2-methyl-2-pentene (8 ml) in tert-butanol (32 ml) was added a solution of sodium chlorite (1.36 g, 0.12 mmol) in H2O (12 ml) containing sodium dihydrogen phosphate (1.07 g, 8.9 mmol) and the mixture was stirred vigorously for 20 min at room temperature. Solvents were concentrated in vacuo and the residue was diluted with H2O, extracted with EtOAc (3×), extracts combined, dried (Na2SO4), and concentrated in vacuo to give the title compound (180 mg, 56%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09095590B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-8596321d901a479c9e425321b867d8fa |
| 출처 메모 | uspto-grants-2015_08 |