Chloro(diphenyl)silane → 2-Benzyl-5-methoxy-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole

HRID 508523

반응식

HRID 508523 반응식
Cl[SiH](C1C=CC=CC=1)C1C=CC=CC=1.[CH2:15]([N:22]1[CH2:36][CH:25]2[C:26]3[CH:27]=[C:28]([O:34][CH3:35])[CH:29]=[CH:30][C:31]=3[CH:32](O)[CH:24]2[CH2:23]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>ClCCCl>[CH2:15]([N:22]1[CH2:23][CH:24]2[CH2:32][C:31]3[CH:30]=[CH:29][C:28]([O:34][CH3:35])=[CH:27][C:26]=3[CH:25]2[CH2:36]1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

참가 물질

4

반응물 2

HCID 74206Chloro(diphenyl)silaneHCID 672032982-Benzyl-5-methoxy-1,2,3,3a,8,8a-hexahydro-2-aza-cyclopenta[a]inden-8-ol

생성물 1

HCID 672033932-Benzyl-5-methoxy-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

반응 조건

온도
60 °C

실험 절차

InCl3 (0.38 g, 1.7 mmol) and chlorodiphenylsilane (1.3 mL, 6.8 mmol) were added to a solution of 2-benzyl-5-methoxy-1,2,3,3a,8,8a-hexahydro-2-aza-cyclopenta[a]inden-8-ol (3.4 mmol) in DCE (17 mL), and stirred overnight at 60° C. The reaction mixture was washed with H2O, a saturated aqueous NaHCO3 solution and brine. The organic extracts were dried over MgSO4 and concentrated. The crude product was obtained without further purification. MS calculated for C19H21NO+H: 280, observed: 280.

후처리

  1. washThe reaction mixture was washed with H2O
  2. dry with materialThe organic extracts were dried over MgSO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-edd26cedf34d48ad9926b2d342b62b41
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096520B2

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