Piperidine → 4-N-(3-bromophenyl)-6-N,6-N-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine

HRID 50853노트

반응식

HRID 50853 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[NH:5][C:6]1[C:7]2[CH:15]=[C:14](F)[N:13]=[CH:12][C:8]=2[N:9]=[CH:10][N:11]=1.[NH:20]1[CH2:25]CCC[CH2:21]1>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[NH:5][C:6]1[C:7]2[CH:15]=[C:14]([N:20]([CH3:25])[CH3:21])[N:13]=[CH:12][C:8]=2[N:9]=[CH:10][N:11]=1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 5328260N-(3-bromophenyl)-6-fluoropyrido[3,4-d]pyrimidin-4-amine

생성물 1

HCID 53282614-N-(3-bromophenyl)-6-N,6-N-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Treatment of 4-(3-bromoanilino)-6-fluoropyrido[3,4-d]pyrimidine (see a previous experimental) at 100° C. in a pressure vessel with piperidine in ethanol gives 4-(3-bromoanilino)-6-dimethylaminopyrido[3,4-d]pyrimidine.

후처리

  1. customat 100° C.

출처 및 근거

ORD 기록
ord-b0306e848834478cab6f5eee129bab6b
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713484B2

반응 노트

불러오는 중…