3-(2-Fluoro-6-nitrophenyl)propanoic acid → 5-Fluoro-3,4-dihydroquinolin-2(1H)-one
반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[CH2:11][CH2:12][C:13]([OH:15])=O>CO.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[CH2:11][CH2:12][C:13](=[O:15])[NH:8]2참가 물질
4
실험 절차
The suspension of 3-(2-fluoro-6-nitrophenyl)propanoic acid (6.0 g, 28 mmol) and 10% Pd-C (300 mg) in MeOH was hydrogenated under H2 (4 atm) for 3 h. After filtration, the filtrate was concentrated in vacuo to afford 5-Fluoro-3,4-dihydroquinolin-2(1H)-one (4.6 g) as a slightly brown solid. This crude product was used in the next step without further purification.
후처리
- filtrationAfter filtration
- concentrationthe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-b40c29e6a78948fdbef5b0ea2d4d3f58
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06713490B2
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