Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (E)-1-(4-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-(2-Phenylethenyl)-1h-benzimidazole | HCID 242965 | — |
| 반응물 | 2-Fluoro-4-methylpyridine | HCID 2737403 | — |
| 반응물 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (E)-1-(4-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride | HCID 22736699 | — |
반응 단계
Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-fluoro-4-methylpyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound. MW: 358.68; mp: 221.0-222.5° C.; 1H-NMR (DMSO) δ: 8.66 (1H, d, J=5.1 Hz), 8.22-8.15 (1H, m), 7.86 (1H, d, J=7.7 Hz), 7.71-7.66 (3H, m), 7.59-7.44 (7H, m), 7.20 (1H, d, J=16.1 Hz), 2.53 (3H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713482B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-e7563a17df69493da72aa3c4147489d9 |
| 출처 메모 | uspto-grants-2004_03 |