Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalyl chloride → 2-Chloro-6-fluorobenzoyl isocyanate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 2-Chloro-6-fluorobenzamide | HCID 98564 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | 2-Chloro-6-fluorobenzoyl isocyanate | HCID 13051731 | 91,106.602% |
반응 단계
To a solution of 2-chloro-6-fluorobenzamide (2.0 g, 0.011 mmol) in EDC (10 mL) was added oxalyl chloride (2.18 g, 0.017 mmol). The reaction mass was refluxed for 24 h. Excess of solvent was removed under vacuum to afford 2.0 g of desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09096545B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-0820864e80534bdb9430b8e948041a85 |
| 출처 메모 | uspto-grants-2015_08 |