Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (E)-1-(6-Fluoropyridin-2-yl)-2-styryl-1H-benzimidazole hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2,6-Difluoropyridine | HCID 73934 | — |
| 반응물 | 2-(2-Phenylethenyl)-1h-benzimidazole | HCID 242965 | — |
| 반응물 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | (E)-1-(6-Fluoropyridin-2-yl)-2-styryl-1H-benzimidazole hydrochloride | HCID 22736651 | — |
반응 단계
Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2,6-difluoropyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was dissolved into diethyl ether and hydrogen chloride gas was passed through the ether solution. Filtration and drying under vacuum yielded the titled compound as pale yellow solids. MW: 351.81; mp: 198.0-205.0° C.; 1H-NMR (DMSO-d6) δ: 8.43 (1H, ddd, J=8.1, 8.1, 8.1 Hz), 8.26 (1H, d, J=16.1 Hz), 7.90-7.80 (2H, m), 7.76-7.69 (2H, m), 7.66-755 (3H, m), 7.54-7.43 (4H, m), 7.28 (1H, d, J=16.1 Hz).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713482B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-0bc055b36fde4321966e8386c9ed2cc7 |
| 출처 메모 | uspto-grants-2004_03 |