Oxalyl chloride → 6-Chloro-2-fluoro-3-(pivalamidomethyl)benzoyl isocyanate
반응식
[Cl:1][C:2]1[C:7]([C:8]([NH2:10])=[O:9])=[C:6]([F:11])[C:5]([CH2:12][NH:13][C:14](=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16])=[CH:4][CH:3]=1.C(Cl)(=O)[C:21](Cl)=[O:22]>C(Cl)CCl>[Cl:1][C:2]1[C:7]([C:8]([N:10]=[C:21]=[O:22])=[O:9])=[C:6]([F:11])[C:5]([CH2:12][NH:13][C:14](=[O:19])[C:15]([CH3:16])([CH3:18])[CH3:17])=[CH:4][CH:3]=1참가 물질
4
반응 조건
- 온도
- 65 °C
실험 절차
To a solution of 6-chloro-2-fluoro-3-(pivalamidomethyl)benzamide (0.300 g, 1.04 mmol) in EDC (10 mL) was added oxalyl chloride (0.11 mL, 1.25 mmol). The reaction mass was heated at 60-70° C. for 4-5 h. Excess of solvent was removed under vacuum to afford 1.0 g of desired product.
후처리
- customExcess of solvent was removed under vacuum
출처 및 근거
- ORD 기록
- ord-2da01bbf67b94645a6b7413da201026c
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09096545B2
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