Ammonia → 3-((2,2,2-Trifluoroacetamido)methyl)-2,6-dimethylbenzamide

HRID 508847노트

반응식

HRID 508847 반응식
[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([CH3:17])=[C:9]([C:13]([CH3:16])=[CH:14][CH:15]=1)[C:10](O)=[O:11])=[O:4].C(Cl)(=O)C(Cl)=O.[NH3:26]>C1COCC1>[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([CH3:17])=[C:9]([C:13]([CH3:16])=[CH:14][CH:15]=1)[C:10]([NH2:26])=[O:11])=[O:4]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 866922272,6-Dimethyl-3-((2,2,2-trifluoroacetamido)methyl)benzoic acid

생성물 1

HCID 900191333-((2,2,2-Trifluoroacetamido)methyl)-2,6-dimethylbenzamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 3((2,2,2-trifluoroacetamido)methyl)-2,6-dimethylbenzoic acid (1.0 g), oxalyl chloride (1.0 mL), THF (50 mL) and ammonia gas to afford 0.800 g of the desired product.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-61304cec033b4ec8b395ff9e9289a87d
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096545B2

반응 노트

불러오는 중…