Oxalyl chloride → 5-((2,2,2-Tri fluoroacetamido)methyl)-2-chloro-4-fluorobenzoyl isocyanate

HRID 508853노트

반응식

HRID 508853 반응식
[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([F:17])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12]([NH2:14])=[O:13])=[O:4].C(Cl)(=O)[C:21](Cl)=[O:22]>C(Cl)CCl>[F:19][C:2]([F:18])([F:1])[C:3]([NH:5][CH2:6][C:7]1[C:8]([F:17])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12]([N:14]=[C:21]=[O:22])=[O:13])=[O:4]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 900195175((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzamide

생성물 1

HCID 900189655-((2,2,2-Tri fluoroacetamido)methyl)-2-chloro-4-fluorobenzoyl isocyanate

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-fluorobenzamide (1.0 g, 3.6 mmol), oxalyl chloride (1.0 mL) and EDC (10 mL) to afford 0.750 g of the desired product.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-151790278dd24fde94f86fd44b829ee4
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096545B2

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