Oxalyl chloride → 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoyl isocyanate

HRID 508863노트

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HRID 508863 반응식
[F:1][C:2]([F:20])([F:19])[C:3]([NH:5][CH2:6][C:7]1[C:8]([O:17][CH3:18])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12]([NH2:14])=[O:13])=[O:4].C(Cl)(=O)[C:22](Cl)=[O:23]>C(Cl)CCl>[F:20][C:2]([F:1])([F:19])[C:3]([NH:5][CH2:6][C:7]1[C:8]([O:17][CH3:18])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12]([N:14]=[C:22]=[O:23])=[O:13])=[O:4]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 900189015-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4 methoxybenzamide

생성물 1

HCID 900198525-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoyl isocyanate

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-methoxybenzamide (1.0 g, 3.6 mmol), oxalyl chloride (1.0 mL) and EDC (10 mL) to afford 0.750 g of the desired product.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-658f6c861d914f0982b2fa342e7c6f56
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096545B2

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