Oxalyl chloride → 5-Cyano-2-(difluoromethyl)nicotinoyl isocyanate

HRID 508908노트

반응식

HRID 508908 반응식
[C:1]([C:3]1[CH:4]=[N:5][C:6]([CH:12]([F:14])[F:13])=[C:7]([CH:11]=1)[C:8]([NH2:10])=[O:9])#[N:2].C(Cl)(=O)[C:16](Cl)=[O:17]>C(Cl)Cl>[C:1]([C:3]1[CH:4]=[N:5][C:6]([CH:12]([F:14])[F:13])=[C:7]([CH:11]=1)[C:8]([N:10]=[C:16]=[O:17])=[O:9])#[N:2]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 900193735-Cyano-2-(difluoromethyl)nicotinamide

생성물 1

HCID 900192245-Cyano-2-(difluoromethyl)nicotinoyl isocyanate수율 88.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 5-cyano-2-(difluoromethyl)nicotinamide (1.0 g), oxalyl chloride (3.2 g, 25.3 mmol) and DCM (20 mL) to afford 1.0 g of the desired product.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-160659bb427b4d3d8fd720fb3668c625
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09096545B2

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